Bayesian inverse problems and epidemic-threshold uncertainty for a heterogeneous SIS reaction-diffusion model

Abstract

We study Bayesian inference of persistence from early observations of a heterogeneous susceptible--infected--susceptible (SIS) reaction--diffusion model with standard incidence. We show that the leading prevalence dynamics depend on the unknown coefficients only through the difference between the transmission and recovery rates and the infected diffusivity. The same pair determines the principal eigenvalue whose sign governs persistence, so early prevalence can inform the threshold even when the individual rates remain uncertain. We prove global weak well-posedness and quantitative parameter stability for the SIS system and use the resulting observation-map estimates to establish Bayesian well-posedness. For an initial infection of size $\varepsilon$, we derive a uniform second-order expansion that describes how the separate rates enter prevalence. Incidence depends explicitly on transmission at leading order. When the noise standard deviation is proportional to $\varepsilon$, we prove $O(\varepsilon)$ convergence in Hellinger distance of the nonlinear posteriors to their low-prevalence limits for both prevalence alone and joint prevalence and incidence data. We bound the principal